In the 12 h-treated cell line, NCI-H522, the levels of HER2, AKT, and Raf-1 all showed a decreasing trend, implying that the inhibition of proliferation of NCI-H522 by 12 h might be related to the reduction of these HSP90 client proteins [ 95 ].
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Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies.
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