Disease burden comparison and associated risk factors of early- and late-onset neonatal sepsis in China and the USA, 1990-2019.

A decreasing trend in the DALYs due to neonatal sepsis caused by short gestation and low birthweight in both sexes was observed in both countries, whereas a fluctuating increasing trend in years lived with disability was observed in China.

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Male neonates with late-stage neonatal sepsis in China had the highest decreasing trend values between the two age groups stratified by country; however, a slightly increasing trend in DALYs due to short gestation (APC: −1.7; 95% CI: −2.0, −1.4) and low birthweight (APC: −2.3; 95% CI: −2.7, −2.0) was observed in both groups between 2013 to 2019.

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Discussion Overall, the results of the present study revealed an increasing trend in the incidence and prevalence of early- and late-onset neonatal sepsis in China between 1990 and 2019 compared with that in the USA, which is consistent with the findings of Tao Pan et al.

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