Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics.

When we compared average read count to fold change in poly(A) tail lengths between 4SA and 4SD cells, the number of genes with significantly longer tails increased with read count ( Supplementary Figure S6C ), highlighting the possibility that the observed difference in poly(A) tail length is indeed transcriptome-wide, but highly expressed genes are more likely to be significant in our sequencing-based method.

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