Global, regional, and national burdens of leukemia from 1990 to 2019: A systematic analysis of the global burden of disease in 2019 based on the APC model.

3.3.2 Period Effect From 1990 to 2019, the global RR of leukemia incidence showed an increasing trend with a growth rate of 27.1%, in which the increase was greater in male (34.4%) than in female (20.3%), and our findings suggest a gradual increase in the incidence of leukemia over time (Table 3 , Figure 6A ).

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The ASIR (estimated annual percentage change (EAPC) = −0.37, 95%UI −0.46 to −0.28) and the age‐standardized DALY rate (EAPC = −1.72, 95%UI −1.80 to −1.65) of leukemia showed a decreasing trend from 1990 to 2019.

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