Epitranscriptomic reader YTHDF2 regulates SEK1(<i>MAP2K4</i>)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.

In this regard, YTHDF2 has been highlighted in certain cellular contexts, including hypoxia, survival/apoptosis, proliferation, and inflammation, and has been shown to directly target secretory mRNAs such as IL-11, 29 transcription factor RELA, and MAP kinases, 30 , 31 , 32 revealing that YTHDF2’s reader function may be highly significant in inflammation.

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In this study, we observed a decreasing trend in YTHDF2 levels in Mn-treated mice as in our preliminary study, approximately ≤20% ( Figure 4 F).

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