We observed a weak trend of P2 -192C>G producing increased FL levels compared with the P2 WT promoter for overexpressed HNF-1A, but the difference was absent when probing for activities of endogenous HNF-1A ( Figure 7B ).
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Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
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