Noninflammatory 97-amino acid High Mobility Group Box 1 derived polypeptide disrupts and prevents diverse biofilms.

A-B Box and B Box-97 peptides retained highly significant anti-biofilm activity against all pathogens tested when analyzed by both parametric and non-parametric one-way ANOVA (P = 0.004–P < 0.0001; with the exception of A-B Box tested against NTHI, which; although normally distributed and statistically significant by parametric one-way ANOVA, approaches significance (P = 0.055) when analyzed by nonparametric one-way ANOVA)) ( Fig. 2 A).

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