Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistant <i>Acinetobacter baumannii</i> by structure-based virtual screening and biological evaluation.

This is consistent with BfmR’s characteristics as a transcription factor capable of activating or inhibiting the transcription of diverse genes. Setting Siph-1 as a reference inhibitor for its reported BfmR inhibitory activity and binding pose, we noticed that the conformational dynamics of BfmR were less significant when combined with agonists or modulators, but markedly significant when combined with inhibitors ( Figure 7 ).

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