Beyond the base pairs: comparative genome-wide DNA methylation profiling across sequencing technologies.

However, for platform-specific CpGs, DNBSEQ has a higher percentage of hypermethylated CpGs and a lower percentage of hypomethylated CpGs compared to NovaSeq, resulting in an increasing trend in hypermethylated CpGs and a decreasing trend in hypomethylated CpGs across NovaSeq-specific, shared, and DNBSEQ-specific CpGs ( Fig. 3k ).

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