Disease prediction with multi-omics and biomarkers empowers case-control genetic discoveries in the UK Biobank.

An example is apolipoprotein B ( APOB ) – E05 thyrotoxicosis (hyperthyroidism) association which achieved P = 9.02 × 10 −9 in pan-ancestry analysis but had borderline significance ( P = 1.77 × 10 −8 ) in EUR-specific analysis.

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This identified several putative novel gene–phenotype associations that did not achieve significance in the baseline PheWAS from the same test cohort.

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