• TLS can provide indicative significance for the efficacy of anti-tumor therapy in HNSCC patients. • Inducing TLS production in tumors to increase anti-tumor immune response is considered an attractive treatment strategy for HNSCC.
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• TLS can provide indicative significance for the efficacy of anti-tumor therapy in HNSCC patients. • Inducing TLS production in tumors to increase anti-tumor immune response is considered an attractive treatment strategy for HNSCC.