To validate these findings, we performed a quantitative analysis of 5hmC level using liquid chromatography-mass spectrometry (LC–MS/MS), and confirmed an increasing trend in 5hmC levels from DCIS to IDC (Fig. 1 e).
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Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis.
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