CXCL12 Gene Polymorphisms and Serum Levels: Associations with Multiple Sclerosis Prevalence and Clinical Parameters in Lithuania.

Additionally, in the men, there was a tendency, which almost reached statistical significance, of lower pyramidal symptom prevalence in the individuals with the rs1801157 TT genotype when compared with the other genotypes ( p = 0.02).

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Furthermore, our data show lower pyramidal symptom prevalence among the male subjects with the rs1801157 TT genotype when compared with the other genotypes, although the results narrowly missed statistical significance, possibly due to the rarity of this genotype in our sample.

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rs1029153 and rs2297630 (3′ UTR and intron variants, respectively) have been implicated as possibly significant in other diseases, such as type 2 diabetes, primary pediatric immune thrombocytopenia, and response to hepatitis C treatment [ 19 , 20 , 21 ], which indicates that these SNPs may have an impact on CXCL12 expression.

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