Association of time and comorbid conditions on prevalence of use of GDMT for HFrEF Overall, the prevalence of use showed an increasing trend in the last 10 years for β-blockers, RAS inhibitors, and MRAs, while it was decreasing for diuretics ( Figures 3 and 4 ).
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Use of Guideline-Recommended Heart Failure Drugs in High-, Middle-, and Low-Income Countries: A Systematic Review and Meta-Analysis.
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