Kinetic analysis of the role of the tyrosine 13, phenylalanine 56 and glutamine 54 network in the U1A/U1 hairpin II interaction.

However, the difference in k d was highly significant ( P < 0.001), supporting the idea that the loss in stability of the Tyr13Phe complex is due to the absence of the hydroxyl bond to Gln54, which would normally stabilize the stacking interaction at position 13, as well as help position the β2–β3 loop in the RNA loop ( 43 ).

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