Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.

6 ) reveal an overall trend similar to the qPCR results, but curiously the difference lessens when focused on exon 1 of Klotho , except for the low amount of reads in E1 KO females, again indicating presence of a sexually dimorphic promoter element remaining active in E1 KO males (Fig. 4d, e ).

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