Broad range molecular detection methods identify only <i>Borrelia</i> spp. in erythema migrans biopsies and blood of tick-bitten patients.

Clinically, only lesion size was almost significantly greater in the “suggestive” group (median [IQR] = 13 [9–19]cm) than in the “not very typical” group (median [IQR] = 8 [6–15]cm) ( p = 0.06) ( Table 1 ), as expected by the classification criteria.

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