Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder.

Mol Psychiatry · 2024 · PMC11408248 · PMID 38355785

Europe PMC DOI

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borderline significantP = 0.01actually significant

Likewise, the finding that higher global functioning (as measured with GAF) was associated with higher BD-PRS and lower SCZ-PRS (borderline significant, P = 0.01) aligns with the Kraepelinian notion that schizophrenia features a chronic deteriorating course with persistent impairment, whereas individuals with BD are typically symptom-free when recovered from mood episodes.

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