Human NGF "Painless" Ocular Delivery for Retinitis Pigmentosa: An In Vivo Study.

The results showed an expected trend, with increased arg1 expression and nos2 downregulation in hNGFp-treated retinas, although the observed differences between the control and treated groups were not statistically significant ( Fig. 2 C ).

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Among genes related to the inflammation pathway, expected to react to hNGFp administration, a highly significant increased expression was exhibited by tmem119, a type I transmembrane protein specifically expressed by homeostatic microglia at various levels in different pathological conditions ( Ruan and Elyaman, 2022 ).

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