Effects of Glucagon-like Peptide-1 Receptor Agonists on Cardiac Function, Exercise Capacity and Quality of Life.

Patients with HFrEF and concomitant T2D show consistently lower Kansas City Cardiomyopathy Questionnaire (KCCQ) scores than those without T2D.[ 49 ] Similarly, higher BMI has detrimental effects on perceived health in HFrEF, which is also highly significant in HFpEF.[ 51 – 53 ] Notably, of the different HF phenotypes, HFpEF is associated with the worst HRQoL, whereas among HFpEF patients, the worst HRQoL had been shown in a subgroup with the highest BMI, a higher proportion of at least Grade 2 obesity and T2D.[ 53 ] Moreover, there was a linear relationship between HRQoL and BMI.[ 53 ] Better T2D control and weight reduction with GLP-1 RA therapy may be beneficial in terms of patient-reported health status among the HF cohort.

also in 132,142 other papers