TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid.

J Biol Chem · 2024 · PMC11416269 · PMID 39159814

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a decreasing trendno p-value reported

Notably, the colocalization of HS and TREM2 showed a decreasing trend in C20 cells with individual knockdowns of either Hs6st1 or Hs6st3 .

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