Cognitive activity significantly affects the dynamic cerebral autoregulation, but not the dynamic vasoreactivity, in healthy adults.

The difference for the 3 rd PDM gain of the ABP input was borderline significant ( p = 0.050), inviting some thoughts about its mechanism of origin (see Discussion). 4 Discussion The regulation of cerebral blood flow is achieved through intricate coordination of multiple homeostatic mechanisms driven by mechanical signaling (e.g., blood pressure variations) and/or chemical signaling (e.g., blood gas variations) occurring systemically throughout the cerebrovascular and autonomic nexus ( Willie et al., 2014 ).

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