Incidence of Malignancies and the Association with Biological Disease-Modifying Antirheumatic Drugs in Japanese Patients with Rheumatoid Arthritis: A Time-Dependent Analysis from the IORRA Patient Registry.

The decrease in lung cancer incidence over time may be partly due to a decreasing trend in smoking in the patients of the IORRA cohort, as evidenced by the lower proportion of current smokers in the 2013–2018 cohort compared with the 2000–2013 cohort (9.2% versus 17.3%, respectively) [ 7 ].

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