Pre-metastatic niche: formation, characteristics and therapeutic implication.

Signal Transduct Target Ther · 2024 · PMC11422510 · PMID 39317708

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highly significantno p-value reported

The process of ECM remodeling is highly significant in facilitating the settlement of CTCs within the PMN. 24 , 189 , 190 Secretory factors emanating from the primary tumor can influence the expression of ECM structural proteins, ECM-degrading enzymes, and ECM-processing proteins within the PMN, thereby facilitating ECM remodeling and contributing t

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