HBcrAg values may predict virological and immunological responses to pegIFN-α in NUC-suppressed HBeAg-negative chronic hepatitis B.

In particular, core-specific and envelope (env)-specific CD4 T cell responses showed a significant inverse correlation with baseline HBcrAg values (core p=0.024; env p=0.034), whereas among CD8 T cells, a correlation was detected for the overall CD8 T cell population (p=0.048; figure 5E , left panels), with a trend very close to statistical significance for env-specific CD8 T cell responses (p=0.051, figure 5E ).

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