Effect of oral or subcutaneous administration of cyanocobalamin in hypocobalaminemic cats with chronic gastrointestinal disease or exocrine pancreatic insufficiency.

9 Our study showed a decreasing trend of serum cobalamin concentrations at the second recheck (evaluated 1 week after discontinuing the cobalamin supplementation) compared to the first recheck.

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The results of 2 previous studies using intramuscular supplementation with either cyano‐ or hydroxocobalamin described the similar pattern showing a decreasing trend of serum cobalamin concentrations and an increasing trend of serum MMA concentrations at the rechecks up to 4 to 10 weeks postcompletion of supplementation. 29 , 30 Until further research is completed, repeated measurements of serum cobalamin concentrations after discontinuation of supplementation might be beneficial to evaluate the need for continued cobalamin supplementation.

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