observed significant decreases in glucose and HbA1c levels in overweight/obese and T2DM subjects after 12 weeks of supplementation with HT-enriched whole wheat bread, with a significantly greater decrease in the fasting glucose levels in the intervention group compared to the control group, and a marginally significant difference in HbA1c levels between the intervention and control groups [ 39 ].
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Systemic Health Effects of Oleuropein and Hydroxytyrosol Supplementation: A Systematic Review of Randomized Controlled Trials.
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While a decreasing trend was noted in these outcomes, subgroup analyses by age, health status, dose, and duration of extra virgin olive oil intake did not significantly alter the results [ 72 ].