The number of patients exceeding and the average number of prescribed MDDs did not indicate an increasing trend of high-dose prescriptions compared to past analyses [ 2 , 16 ] and support the conclusions that there are still no signs of an opioid crisis in Germany [ 7 , 8 ].
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Exceeding the guideline-recommended maximum daily dose of opioids for long-term treatment of non-cancer pain in Germany - a large retrospective observational study.
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