Metabolic Reprogramming of CD4⁺ T Cells by Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuates Autoimmune Hepatitis Through Mitochondrial Protein Transfer.

Interestingly, we detected an increasing trend of EV signals in the livers of AIH mice compared with those of normal mice, suggesting greater liver uptake or retention of EVs in AIH mice than in normal mice ( Figure 5A and B , Figure S1A ), which may be due to vascular injury in AIH mice, which increases the leakage of EVs into damaged liver tissues.

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