Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma.

Nat Commun · 2024 · PMC11437149 · PMID 39333105

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0.0006

closest p · 0.0× alpha

0.0770

boldest claim

The sentences

a decreasing trendP = 0.0006actually significant

Interestingly, we observed a decreasing trend in the correlation coefficient between germline variant burden and somatic mutational burden (Jonckheere-Terpstra test, P = 0.0006; Fig. 2d ).

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a trend towards significanceP = 0.077so close (0.05 < p ≤ 0.1)

In the SMC cohort, we observed a trend towards significance ( P = 0.077; Odds Ratio, 1.45; 95% CI, 0.94−2.21) compared to KOREA1K, while in the TARGET cohort, we found a statistically significant difference ( P = 0.027; Odds Ratio, 1.46; 95% CI, 1.04−2.05) compared to the TCGA cohort.

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borderline significantP = 0.077so close (0.05 < p ≤ 0.1)

The enrichment of putatively functional germline variants in cancer predisposition genes is borderline significant when compared to healthy populations ( P = 0.077; Odds Ratio, 1.45; 95% confidence intervals, 0.94−2.21) and significantly more pronounced against adult-onset cancers ( P = 0.016; Odds Ratio, 2.13; 95% confidence intervals, 1.10−3.91).

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