HSV-2 Manipulates Autophagy through Interferon Pathway: A Strategy for Viral Survival.

Similarly, IRF9, a component of the ISGF3 complex, also showed an increasing trend in its protein level over time after HSV-2 infection, further supporting the activation of the JAK-STAT pathway in response to HSV-2 infection, and the potential formation of the ISGF3 complex ( Figure 4 ).

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