highly significantp < 0.01
The LOCC incorporates significance, range, and impact and is calculated by multiplying these three components together, represented by the equation: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$LOCC \,Score={p}_{l}* {R}_{s}* {HR}_{p}$$\end{document} L O C C S c o r e = p l ∗ R s ∗ HR p where p l is the highest value of − log ( p value), R s is the percentage of cutoffs that have a highly significant p value ( p < 0.01), and HR p is the HR at the most significant point.