BTN3A1 expressed in cervical cancer cells promotes Vγ9Vδ2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling.

Compared with those in the BTN3A1-WT group, the expressions of NR4A2/3 in Vδ2 T cells of the BTN3A1-KO group were lower, while showed an increasing trend in the BTN3A1-OE group (Fig. 4 E and Figure S6C).

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