marginally significantp = 0.06
Despite no significant difference in system segregation between decliners and non-decliners ( Figure 4B ), the final MMSE scores in decliners displayed a strong but marginally significant association with system segregation for all canonical networks and DMN (rho = 0.59, p = 0.06; rho = 0.57, p = 0.07) and a significant association with system segregation for SMN (rho = 0.67, p = 0.03) ( Figure 5B ).