Microbiota-derived tryptophan metabolism and AMPK/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction.

Following CUS stimulation, there was a notable trend of decreased total movement distance ( p < 0.05), number of crossing central areas ( p < 0.01), and rised stationary time ( p < 0.01).

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The treatment with SHD and FOS showed an increasing trend in Bacteroidota, but a downward trend in the abundance of Firmicutes, Actinobacteria compared to the CUS model group ( Figure 2A ).

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