The GSEA results of the host genes largely mirrored those of the phage genes, with host genes in the RBP_data not showing significance but exhibiting an increasing trend ( Supplementary Fig.
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DeepPBI-KG: a deep learning method for the prediction of phage-bacteria interactions based on key genes.
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This also explains why there was an overall trend towards upregulation despite the nonsignificant GSEA results, indicating a discrepancy between the predicted and manually selected genes.