Implications of accumulation of clonally expanded and senescent CD4⁺GNLY⁺ T cells in immunological non-responders of HIV-1 infection.

Furthermore, although the expression of EOMES increased after ART ( P = 0.0055, Figure 2 (F)), it cannot be ignored that CX3CR1, EOMES, and T-bet were significantly reduced in INRs compared to IRs ( P = 0.0185 for CX3CR1, P = 0.0175 for EOMES, and P = 0.0147 for T-bet, Figure 2 (C,F,G)), and the GZMB also showed a decreasing trend ( Figure 2 (E)), which highlight the cytotoxicity of clonally expanded CD4 + GNLY + T cells, and the cytotoxicity is weakened in INRs compared to IRs even after ART.

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