Oncogenic MTOR Signaling Axis Compensates BTK Inhibition in a Chronic Lymphocytic Leukemia Patient with Richter Transformation: A Case Report and Review of the Literature.

Additionally, MSigDB Hallmark gene sets involved in cell cycle progression (G2M checkpoint, E2F targets, Myc targets, P53 pathway, and mitotic spindle), immune regulation (inflammatory response, interferon gamma response, allograft rejection), DNA damage (DNA repair, UV response down), and oxidative phosphorylation also showed a highly significant activation ( Fig. 2 a).

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