Recombinant neorudin and its active metabolite hirudin: the fate <i>in vivo</i> of a novel anticoagulant drug.

Detection of neorudin and hirudin in peripheral blood plasma The concentration of neorudin in the peripheral blood plasma of groups receiving 3 mg/kg, 6 mg/kg, 12 mg/kg, and 18 mg/kg showed an increasing trend with the dosage of neorudin administered during continuous administration for 15 min and 1 h, as well as at 1 h after discontinuation ( Figure 3A ).

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