In contrast to MG63.3, orthotopic MNNG xenografts formed spontaneous lung metastases, and the CR-1-31B–treated group demonstrated a highly significant reduction in lung metastasis by eGFP IHC in Fig. 2F , with quantification in Fig. 2G .
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Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis.
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