Integrins linked kinase and focal adhesion kinase as the key signaling mediators of vascular mimicry in metastatic breast tumor cells.

Down-regulation of ILK, FAK in primary breast cancer compare to fibroblast cell line as control sample (3T3 cell line) Interestingly, examination the expression level of ILK , FAK in primary breast cancer relative to fibroblast cell line (control sample) showed a decreasing trend in these genes (Fig. 1 ).

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