Cluster C7 exhibited highly significant enrichment for binding sites of transcription factors such as Smarcc1 , Bach1 , and Rela , known to drive pro-inflammatory gene activation in macrophages 97 – 99 (Fig. 7D ).
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The frequency of CD38<sup>+</sup> alveolar macrophages correlates with early control of M. tuberculosis in the murine lung.
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