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The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study.

NPJ Aging · 2024 · PMC11447243 · PMID 39358364

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a decreasing trendno p-value reported
There is a non-linear relationship between sleep duration and serum Klotho levels so when sleep duration exceeds 7.5 h, a decreasing trend in S-Klotho level is observed.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.