Mutation of <i>Pseudomonas aeruginosa lasI/rhlI</i> diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages.

Significantly reduced levels of pro-inflammatory cytokines and inflammation-inducing enzymes were observed following treatment with ΔlasI and ΔlasIΔrhlI , accompanied by an elevated trend for the anti-inflammatory cytokine IL-10.

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