No benefit from TMZ treatment in glioblastoma with truly unmethylated MGMT promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly glioblastoma patients.

Neuro Oncol · 2024 · PMC11449086 · PMID 38912869

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0551

boldest claim

The sentences

almost reached statistical significanceP = .055so close (0.05 < p ≤ 0.1)

However, the combination therapy in the unmethylated patients showed an apparent better outcome that almost reached statistical significance when compared to the RT-arm ( P = .055).

also in 74 other papers

almost reached significanceP = .0551so close (0.05 < p ≤ 0.1)

In the original analysis including all unmethylated patients, the comparison almost reached significance ( P = .0551).

also in 59 other papers

almost significantno p-value reported

Based on the CE.6 study 13 that showed almost significant benefit from the addition of TMZ to RT, many patients with tumors without MGMT p methylation receive combination therapy including TMZ with the hope of improving outcomes.

also in 375 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.