Investigation of serum neurofilament light chain as a biomarker in Fabry disease.

Sci Rep · 2024 · PMC11449901 · PMID 39362930

Europe PMC DOI

hedged sentence

0.0940

closest p · 1.9× alpha

0.0940

boldest claim

The sentences

failed to achieve significancep = 0.094so close (0.05 < p ≤ 0.1)

While we found significantly lower sNfL absolute values in treatment naïve PwFD (median 9.7 pg/mL, IQR 7.7) compared to those receiving any disease-specific therapy (ERT or chaperone-therapy, 16.3 pg/mL, IQR 20.6, p = 0.015), this difference failed to achieve significance when analyzing sNfL Z-scores (0.75, SD 1.6 vs. 1.48, SD 1.4; p = 0.094, Table 4 ).

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