Following an increasing trend between 2014 and 2016, the administration of nifedipine with lidocaine [682 (26.2%) subjects] slightly decreased over time.
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Temporal trends and treatment patterns in anal fissure management: insights from a multicenter study in Italy.
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Scenario B—hypertonic internal anal sphincter Out of 8050 patients, conservative therapy was administered in 6055 (75.2%) cases, with anal dilation, yet performed in 1043 (12.9%) patients, showing a decreasing trend over time.