The results showed that, when compared with the WT littermates, the Lepr −/− obese rats exhibited an increasing trend in NLRP3 expression, while following cerebral ischemia, there was further activation of the NLRP3 inflammasome.
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The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in <i>Lepr<sup>-/-</sup></i> Obese Rats.
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