Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate.

Front Cell Dev Biol · 2024 · PMC11456701 · PMID 39376628

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In contrast, the absence of DNp73 led to a notable decrease in the number of SOX2+ progenitors, accompanied by a highly significant increase in the number of mature neurons (from 8% in WT-mBOs to 50% in DNp73-mBOs).

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