Human gut microbiota-reactive DP8α Tregs prevent acute graft-versus-host disease in a CD73-dependent manner.

A nonsignificant trend toward a decrease for both DP8α Treg frequency ( Figure 8A ) and their CD73 expression ( Figure 8B ) was observed before mobilization in available donors whose grafts triggered aGvHD in patients, suggesting that donors with a reduced frequency of CD73 + DP8α Tregs could already harbor features making them prone to aGvHD development in recipients.

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